Magnesium Malate

Magnesium malate (C₄H₄MgO₅)

Evidence: Strong

Magnesium is one of the body's true workhorses, acting as a cofactor in more than 300 enzymatic reactions. Among its officially recognised roles, magnesium contributes to normal muscle function and to normal energy-yielding metabolism, both of which matter for a digestive tract that is, at its core, a long muscular organ that needs energy to keep working.

We use magnesium malate, in which magnesium is bound to malic acid, a form chosen for good absorption and tolerability. It is a quietly essential part of the formula. Many people fall short of magnesium through diet alone, and topping it up supports the everyday processes that keep the body, and the gut, running as they should.

PubMed indexes over 131,000 peer-reviewed papers on magnesium.

Selected study

Fatima G, Dzupina A, Alhmadi HB, Magomedova A, Siddiqui Z, Mehdi A, Hadi N. Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases. Cureus. 2024;16(10):e71392. doi:10.7759/cureus.71392

Study summary

Study type: Comprehensive narrative review of laboratory, epidemiological and clinical research on magnesium.

Observed benefits:

• Adequate magnesium intake is associated with better cardiometabolic and bone-health markers in population studies.
• Low magnesium status is associated with muscle weakness and fatigue.

Mechanisms: Magnesium acts as a cofactor for more than 300 enzymes, supports the use of cellular energy, and helps regulate muscle and nerve signalling.

Safety: Very high supplemental intakes can cause loose stools; caution is advised for those with impaired kidney function.

Evidence strength: Strong biological plausibility and consistent associations, with the review itself graded as moderate-quality evidence overall.